# SURVIVE HERoes

Source: https://onco.cc/trials/survive-heroes/  
OnCo record `survive-heroes` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A trial that gives trastuzumab deruxtecan to people with HER2-positive or HER2-low breast cancer whose blood shows the cancer returning before anything is seen on scans.

## Summary

SURVIVE HERoes (NCT06643585) randomises 180 planned patients from the SURVIVE surveillance study whose ctDNA turns positive to trastuzumab deruxtecan for 16 cycles (with endocrine therapy if hormone receptor positive) or physician's choice. ctDNA is measured with the RaDaR assay, and the primary endpoint is ctDNA clearance 12 months after randomisation. Patients are selected by the HER2 status of their original tumour, not by testing what has come back. The registry lists primary completion in April 2032.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-11-04
- Also known as: SURVIVE-HERoes
- Registry id: NCT06643585
- Phase: 3
- Setting: Intermediate- to high-risk HER2-positive or HER2-low early breast cancer in the SURVIVE study with molecular relapse (positive ctDNA): trastuzumab deruxtecan, plus endocrine therapy if hormone receptor positive, versus physician's choice, 2:1
- Sponsor: Prof. Wolfgang Janni
- Enrolled: 180

## Sources

- ClinicalTrials.gov NCT06643585: https://clinicaltrials.gov/study/NCT06643585

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [HER2-positive breast cancer](https://onco.cc/cancers/breast-her2-positive/)
- technologies: [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/)
- targets: [HER2](https://onco.cc/targets/her2/)
- drugs: [RaDaR ST](https://onco.cc/drugs/radar-mrd/), [Trastuzumab deruxtecan](https://onco.cc/drugs/trastuzumab-deruxtecan/)
- terms: [Circulating tumour DNA (ctDNA)](https://onco.cc/terms/ctdna/), [Minimal / molecular residual disease (MRD)](https://onco.cc/terms/mrd/), [Tumour-informed versus tumour-naive ctDNA assays](https://onco.cc/terms/tumour-informed-assay/)
- trials: [SURVIVE (intensive versus standard surveillance in early breast cancer)](https://onco.cc/trials/survive-breast-surveillance/)

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