# Susan M. Domchek

Source: https://onco.cc/people/susan-domchek/  
OnCo record `susan-domchek` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Leads the world's first centre dedicated to BRCA-related cancers and the trials of PARP inhibitors plus immunotherapy.

## Summary

Susan M. Domchek is Executive Director of the Basser Center for BRCA at the Abramson Cancer Center, University of Pennsylvania. She leads the world's first centre dedicated to BRCA-related cancers and is known for trials combining PARP inhibitors with immunotherapy, including MEDIOLA with olaparib plus durvalumab, and for analyses of PARP-inhibitor resistance and reversion in germline BRCA carriers. Her selected paper reports the MEDIOLA study of olaparib and durvalumab in germline BRCA-mutated metastatic breast cancer. Her work spans hereditary breast, ovarian and pancreatic cancer and germline testing.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Executive Director, Basser Center for BRCA
- Specialisms: BRCA1/2; Hereditary cancer; PARP inhibitors

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Susan_Domchek
- Basser Center: https://www.basser.org
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Domchek%20SM%5BAuthor%5D

## Connected records

- cancers: [BRCA or PALB2-mutant pancreatic ductal adenocarcinoma](https://onco.cc/cancers/brca-palb2-pdac/), [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Triple-negative breast cancer (TNBC)](https://onco.cc/cancers/tnbc/)
- technologies: [Germline (hereditary) testing](https://onco.cc/technologies/germline-testing/)
- targets: [BRCA1 / BRCA2 (HRD)](https://onco.cc/targets/brca/), [PARP](https://onco.cc/targets/parp/)
- drugs: [Olaparib](https://onco.cc/drugs/olaparib/)
- institutions: [Abramson Cancer Center, University of Pennsylvania](https://onco.cc/institutions/penn-abramson/)
- people: [Angelina Jolie](https://onco.cc/people/angelina-jolie/)
- key papers: [OlympiA: a year of olaparib after surgery for BRCA-mutated, high-risk early breast cancer](https://onco.cc/key-papers/paper-olympia-nejm-2021/), [PROSE consortium: preventive surgery lowers cancer and death in BRCA1 and BRCA2 carriers](https://onco.cc/key-papers/paper-brca-risk-reducing-surgery-jama-2010/)

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