# SUSD2

Source: https://onco.cc/targets/susd2/  
OnCo record `susd2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

SUSD2 (Sushi domain-containing protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.

## Summary

May be a cytokine receptor for GPR15LG. May be a tumour suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Lung Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: sushi domain containing 2; Sushi domain-containing protein 2; BK65A6.2; FLJ22778; W5C5
- Tags: cancer-genes-wave
- Symbol: SUSD2
- Class: oncogene
- Biology: May be a cytokine receptor for GPR15LG. May be a tumour suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis. Location: Cell membrane (UniProt). Locus 22q11.23 (HGNC).
- Where found: Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30667: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30667
- UniProt Q9UGT4: https://www.uniprot.org/uniprotkb/Q9UGT4/entry
- NCBI Gene 56241: https://www.ncbi.nlm.nih.gov/gene/56241
- Ensembl ENSG00000099994: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000099994

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/susd2.json