# Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer

Source: https://onco.cc/trials/symbiotic-gi-16/  
OnCo record `symbiotic-gi-16` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial testing PF-08634404 in gastric & gastro-oesophageal junction cancer and oesophageal cancer, now recruiting.

## Summary

Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer is a phase 2/3 interventional study registered as NCT07392892, led by Pfizer, and recruiting on the registry. Official title: A phase 2/3 interventional study of PF-08634404 in combination with chemotherapy in treatment-naïve participants with locally advanced or metastatic gastric, gastroesophageal junction, or oesophageal adenocarcinoma. Planned enrolment is 840 participants (estimated). The study started in 2026-05-14 and primary completion is expected in 2031-07-22. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Also known as: Symbiotic-GI-16
- Tags: ctgov-ingest
- Registry id: NCT07392892
- Phase: 2/3
- Setting: A phase 2/3 interventional study of PF-08634404 in combination with chemotherapy in treatment-naïve participants with locally advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma
- Sponsor: Pfizer
- Enrolled: 840

## Sources

- ClinicalTrials.gov NCT07392892: https://clinicaltrials.gov/study/NCT07392892

## Connected records

- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Oesophageal and junctional adenocarcinoma](https://onco.cc/cancers/oesophageal-adenocarcinoma/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/)
- drugs: [PF-08634404](https://onco.cc/drugs/pf-08634404/)
- companies: [Pfizer (incl. Seagen)](https://onco.cc/companies/pfizer/)

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JSON: https://onco.cc/api/v1/entities/symbiotic-gi-16.json