# Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Source: https://onco.cc/trials/symbiotic-lung-01/  
OnCo record `symbiotic-lung-01` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing PF-08634404 in non-small-cell lung cancer, now recruiting.

## Summary

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer is a phase 3 interventional study registered as NCT07222566, led by Pfizer, and recruiting on the registry. Official title: An interventional phase 3, double-blind, randomised study to evaluate efficacy and safety of PF-08634404 in combination with chemotherapy versus pembrolizumab in combination with chemotherapy in adult participants with locally advanced or metastatic non-small cell lung cancer. Planned enrolment is 1410 participants (estimated). The study started in 2026-01-06 and primary completion is expected in 2029-02-27. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Also known as: Symbiotic-Lung-01
- Tags: ctgov-ingest
- Registry id: NCT07222566
- Phase: 3
- Setting: An interventional phase 3, double-blind, randomized study to evaluate efficacy and safety of PF-08634404 in combination with chemotherapy versus pembrolizumab in combination with chemotherapy in adult participants with locally advanced or metastatic non-small cell lung cancer
- Sponsor: Pfizer
- Enrolled: 1410

## Sources

- ClinicalTrials.gov NCT07222566: https://clinicaltrials.gov/study/NCT07222566

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [PF-08634404](https://onco.cc/drugs/pf-08634404/)
- companies: [Pfizer (incl. Seagen)](https://onco.cc/companies/pfizer/)

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JSON: https://onco.cc/api/v1/entities/symbiotic-lung-01.json