# TAF15

Source: https://onco.cc/targets/taf15/  
OnCo record `taf15` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TAF15 (TATA-binding protein-associated factor 2N) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Mesothelioma and Pleural mesothelioma.

## Summary

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Pleural Mesothelioma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TATA-box binding protein associated factor 15; TATA-binding protein-associated factor 2N; hTAFII68; RBP56; Npl3; TAF2N
- Tags: cancer-genes-wave
- Symbol: TAF15
- Class: tumor-suppressor
- Biology: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). Location: Nucleus; Cytoplasm (UniProt). Locus 17q12 (HGNC).
- Where found: Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA); Mesothelioma: IntOGen driver in 1 cohort (PLMESO); Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11547: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11547
- UniProt Q92804: https://www.uniprot.org/uniprotkb/Q92804/entry
- NCBI Gene 8148: https://www.ncbi.nlm.nih.gov/gene/8148
- Ensembl ENSG00000270647: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000270647

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Mesothelioma](https://onco.cc/cancers/mesothelioma/), [Pleural mesothelioma](https://onco.cc/cancers/pleural-mesothelioma/)

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JSON: https://onco.cc/api/v1/entities/taf15.json