# TAF1L

Source: https://onco.cc/targets/taf1l/  
OnCo record `taf1l` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TAF1L (Transcription initiation factor TFIID subunit 1-like) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.

## Summary

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Colorectal Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TATA-box binding protein associated factor 1 like; Transcription initiation factor TFIID subunit 1-like
- Tags: cancer-genes-wave
- Symbol: TAF1L
- Class: tumor-suppressor
- Biology: May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. Location: Nucleus (UniProt). Locus 9p21.1 (HGNC).
- Where found: Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18056: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18056
- UniProt Q8IZX4: https://www.uniprot.org/uniprotkb/Q8IZX4/entry
- NCBI Gene 138474: https://www.ncbi.nlm.nih.gov/gene/138474
- Ensembl ENSG00000122728: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000122728

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/taf1l.json