# TAL1

Source: https://onco.cc/targets/tal1/  
OnCo record `tal1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TAL1 (T-cell acute lymphocytic leukaemia protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-Hodgkin lymphoma, Skin cancer and 2 more.

## Summary

Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.90, animal model 0.64, somatic mutation 0.75). IntOGen calls it a driver in 1 cohort (0 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TAL bHLH transcription factor 1, erythroid differentiation factor; T-cell acute lymphocytic leukemia protein 1; bHLHa17; TCL5
- Tags: cancer-genes-wave
- Symbol: TAL1
- Class: transcription
- Biology: Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. Location: Nucleus (UniProt). Locus 1p33 (HGNC).
- Where found: Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908); Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898); Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059); Acute lymphoblastic leukaemia: Open Targets association 0.52 with acute lymphoblastic leukaemia (MONDO_0004967)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11556: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11556
- UniProt P17542: https://www.uniprot.org/uniprotkb/P17542/entry
- NCBI Gene 6886: https://www.ncbi.nlm.nih.gov/gene/6886
- Ensembl ENSG00000162367: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162367

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/tal1.json