# TARE / SIRT (radioembolisation with yttrium-90)

Source: https://onco.cc/terms/tare/  
OnCo record `tare` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Injecting tiny radioactive glass or resin beads into the liver's artery so they lodge in the tumour and irradiate it from inside.

## Summary

Yttrium-90 microspheres (20-60 µm) deliver beta radiation over a few millimetres with a 64-hour half-life, treating hepatocellular carcinoma, colorectal liver metastases and neuroendocrine liver metastases. Randomised trials against sorafenib (SARAH, SIRveNIB) showed no survival gain but better tolerability; radiation segmentectomy, which delivers ablative doses to a small segment, achieves outcomes close to ablation. Dosimetry now individualises the activity (DOSISPHERE). Chosen over TACE when portal vein thrombus is present.

## Fields

- Kind: Term
- Last checked: 2026-09-09
- Also known as: TARE; SIRT; radioembolisation; radioembolization; Y-90; Y90; yttrium-90; selective internal radiation therapy; 90Y microspheres

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Selective_internal_radiation_therapy
- Wikipedia: https://en.wikipedia.org/wiki/Selective_internal_radiation_therapy

## Connected records

- technologies: [Transarterial chemoembolisation (TACE)](https://onco.cc/technologies/tace/)
- terms: [Liver-directed therapy (TACE, TARE, HAI, ablation)](https://onco.cc/terms/liver-directed-therapy/), [Portal vein tumour thrombus (macrovascular invasion)](https://onco.cc/terms/portal-vein-tumour-thrombus/), [TACE (transarterial chemoembolisation)](https://onco.cc/terms/tace-term/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/)
- fronts: [Radiopharmaceuticals & Theranostics](https://onco.cc/fronts/radiopharma/), [Surgery & Interventional](https://onco.cc/fronts/surgery/)

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JSON: https://onco.cc/api/v1/entities/tare.json