# Targeted panel sequencing

Source: https://onco.cc/terms/targeted-panel-sequencing/  
OnCo record `targeted-panel-sequencing` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A targeted panel sequences only a chosen set of a few hundred cancer genes, deeply and cheaply, which is what most hospitals run on tumours today.

## Summary

Exome sequencing works by selecting a subset of DNA before sequencing (Wikipedia); a targeted panel narrows the selection further to hundreds of clinically relevant genes, read at high depth from small samples. Panels such as MSK-IMPACT and FoundationOne underlie AACR Project GENIE, the largest clinico-genomic dataset, but panel coverage differs between institutions, so pooling requires restricting to shared genes and treating unsequenced genes as missing rather than wild type.

## Fields

- Kind: Term
- Last checked: 2026-09-24
- Also known as: targeted panel sequencing; targeted-panel sequencing; gene panel sequencing; targeted gene panel; clinical sequencing panel; hundreds of genes panel
- Tags: cansim-terms

## Notes

- Listed in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme; CanSim page path /terms/targeted-panel-sequencing.

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Exome_sequencing
- AACR Project GENIE: https://www.aacr.org/professionals/research/aacr-project-genie/
- Wikipedia: https://en.wikipedia.org/wiki/Exome_sequencing

## Connected records

- collections: [AACR Project GENIE](https://onco.cc/collections/genie/)
- terms: [Actionable genomic biomarkers](https://onco.cc/terms/cancer-drivers-vs-actionable/), [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Somatic mutations from exome and genome sequencing (WXS, WGS)](https://onco.cc/terms/somatic-mutations-wxs-wgs/)
- technologies: [Comprehensive genomic profiling](https://onco.cc/technologies/cgp/)

---
JSON: https://onco.cc/api/v1/entities/targeted-panel-sequencing.json