# TBL1XR1

Source: https://onco.cc/targets/tbl1xr1/  
OnCo record `tbl1xr1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TBL1XR1 (F-box-like/WD repeat-containing protein TBL1XR1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.

## Summary

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.96, animal model 0.28, genetic association 0.34, somatic mutation 0.83). IntOGen calls it a driver in 9 cohorts (8 activating, 1 loss-of-function), covering Acute Lymphoblastic Leukaemia, Burkitt Lymphoma, Invasive Breast Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Non-Hodgkin Lymphoma and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TBL1X/Y related 1; F-box-like/WD repeat-containing protein TBL1XR1; IRA1; FLJ12894; TBLR1; C21; DC42
- Tags: cancer-genes-wave
- Symbol: TBL1XR1
- Class: transcription
- Biology: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Location: Nucleus (UniProt). Locus 3q26.32 (HGNC).
- Where found: Non-Hodgkin lymphoma: Open Targets association 0.74 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 3 cohorts (MLYM, NHL); Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059); Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA); Mesothelioma: IntOGen driver in 1 cohort (PLMESO); Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903); Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 8 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29529: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29529
- UniProt Q9BZK7: https://www.uniprot.org/uniprotkb/Q9BZK7/entry
- NCBI Gene 79718: https://www.ncbi.nlm.nih.gov/gene/79718
- Ensembl ENSG00000177565: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177565

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Mesothelioma](https://onco.cc/cancers/mesothelioma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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