# TBXT

Source: https://onco.cc/targets/tbxt/  
OnCo record `tbxt` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TBXT (T-box transcription factor T) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Chordoma.

## Summary

Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site.

CIViC holds 5 clinical evidence items and 0 assertions across 3 variants, naming Nivolumab. In OnCo, 1 product record names it (GI-6301).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: T-box transcription factor T
- Tags: cancer-genes-wave
- Symbol: TBXT
- Class: transcription
- Biology: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site. Location: Nucleus (UniProt). Locus 6q27 (HGNC).
- Where found: Chordoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 5 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Poorly Differentiated Chordoma.

## Sources

- HGNC HGNC:11515: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11515
- UniProt O15178: https://www.uniprot.org/uniprotkb/O15178/entry
- NCBI Gene 6862: https://www.ncbi.nlm.nih.gov/gene/6862
- Ensembl ENSG00000164458: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164458

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Chordoma](https://onco.cc/cancers/chordoma/)
- drugs: [GI-6301](https://onco.cc/drugs/gi-6301/)

---
JSON: https://onco.cc/api/v1/entities/tbxt.json