# TCEA1

Source: https://onco.cc/targets/tcea1/  
OnCo record `tcea1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TCEA1 (Transcription elongation factor A protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.

## Summary

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.23, genetic association 0.00, somatic mutation 0.89).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transcription elongation factor A1; Transcription elongation factor A protein 1; TF2S; TFIIS; GTF2S
- Tags: cancer-genes-wave
- Symbol: TCEA1
- Class: transcription
- Biology: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Location: Nucleus (UniProt). Locus 8q11.23 (HGNC).
- Where found: Oral cavity cancer: Open Targets association 0.51 with oral cavity cancer (MONDO_0005515)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11612: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11612
- UniProt P23193: https://www.uniprot.org/uniprotkb/P23193/entry
- NCBI Gene 6917: https://www.ncbi.nlm.nih.gov/gene/6917
- Ensembl ENSG00000187735: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000187735

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Oral cavity cancer (mouth and tongue)](https://onco.cc/cancers/oral-cavity-cancer/)

---
JSON: https://onco.cc/api/v1/entities/tcea1.json