# TCF12

Source: https://onco.cc/targets/tcf12/  
OnCo record `tcf12` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TCF12 (Transcription factor 12) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.

## Summary

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

IntOGen calls it a driver in 2 cohorts (0 activating, 1 loss-of-function), covering Glioblastoma Multiforme, Low-Grade Glioma, NOS.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transcription factor 12; Transcription factor 12; HTF4; HsT17266; bHLHb20; p64
- Tags: cancer-genes-wave
- Symbol: TCF12
- Class: tumor-suppressor
- Biology: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). May be involved in the functional network that regulates the development of the GnRH axis. Location: Nucleus (UniProt). Locus 15q21.3 (HGNC).
- Where found: Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:11623: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11623
- UniProt Q99081: https://www.uniprot.org/uniprotkb/Q99081/entry
- NCBI Gene 6938: https://www.ncbi.nlm.nih.gov/gene/6938
- Ensembl ENSG00000140262: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140262

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)

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JSON: https://onco.cc/api/v1/entities/tcf12.json