# TCF19

Source: https://onco.cc/targets/tcf19/  
OnCo record `tcf19` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TCF19 (Transcription factor 19) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.

## Summary

Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition. May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Mirdametinib and Birabresib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transcription factor 19; Transcription factor 19; SC1
- Tags: cancer-genes-wave
- Symbol: TCF19
- Class: transcription
- Biology: Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition. May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1. Location: Nucleus (UniProt). Locus 6p21.33 (HGNC).
- Where found: Melanoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11629: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11629
- UniProt Q9Y242: https://www.uniprot.org/uniprotkb/Q9Y242/entry
- NCBI Gene 6941: https://www.ncbi.nlm.nih.gov/gene/6941
- Ensembl ENSG00000137310: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137310

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)

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JSON: https://onco.cc/api/v1/entities/tcf19.json