# TCF4

Source: https://onco.cc/targets/tcf4/  
OnCo record `tcf4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TCF4 (Transcription factor 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.

## Summary

Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transcription factor 4; Transcription factor 4; SEF2-1B; ITF2; bHLHb19; E2-2
- Tags: cancer-genes-wave
- Symbol: TCF4
- Class: tumor-suppressor
- Biology: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. Location: Nucleus (UniProt). Locus 18q21.2 (HGNC).
- Where found: Medulloblastoma: IntOGen driver in 1 cohort (MBL); Paediatric low-grade glioma: IntOGen driver in 1 cohort (PAST)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11634: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11634
- UniProt P15884: https://www.uniprot.org/uniprotkb/P15884/entry
- NCBI Gene 6925: https://www.ncbi.nlm.nih.gov/gene/6925
- Ensembl ENSG00000196628: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196628

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/), [Paediatric low-grade glioma](https://onco.cc/cancers/paediatric-low-grade-glioma/)

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JSON: https://onco.cc/api/v1/entities/tcf4.json