# Tempest Therapeutics

Source: https://onco.cc/companies/tempest-therapeutics/  
OnCo record `tempest-therapeutics` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Tempest Therapeutics is a California company developing CAR-T cell treatments, immune cells engineered to find cancer, that target two markers at once. One is made inside the body; the other, made from a patient's own cells, is being tested in multiple myeloma.

## Summary

Tempest Therapeutics, Inc., of Brisbane, California, describes in its August 2026 registration statement a pipeline of chimeric antigen receptor T cell candidates. Its lead programme, TPST-4003, is a dual CD19 and BCMA in vivo CAR-T candidate for immunology and oncology. In February 2026 it acquired rights to a dual-targeting CAR-T platform including TPST-2003, an autologous CD19 and BCMA CAR-T therapy in clinical development for relapsed or refractory multiple myeloma and POEMS syndrome.

## Fields

- Kind: Company
- Last checked: 2026-11-04
- Also known as: Tempest Therapeutics, Inc.
- HQ: Brisbane, CA
- Type: biotech
- Website: https://www.tempesttx.com/
- Ticker: TPST

## Notes

- Read on 4 November 2026 in the S-1 filed with the SEC on 21 August 2026, a resale registration that incorporates the annual report by reference. The filing does not give phases or trial numbers for either candidate.

## Sources

- SEC: Tempest Therapeutics Form S-1, August 2026: https://www.sec.gov/Archives/edgar/data/1544227/000119312526361240/d181522ds1.htm
- Official website: https://www.tempesttx.com/

## Connected records

- fronts: [Cell Therapy](https://onco.cc/fronts/cell-therapy/)
- technologies: [CAR-T cell therapy](https://onco.cc/technologies/car-t/), [In vivo CAR-T](https://onco.cc/technologies/in-vivo-car-t/)
- targets: [BCMA](https://onco.cc/targets/bcma/), [CD19](https://onco.cc/targets/cd19/)
- drugs: [TPST-2003](https://onco.cc/drugs/tpst-2003/), [TPST-4003](https://onco.cc/drugs/tpst-4003/)

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