# TENT4A

Source: https://onco.cc/targets/tent4a/  
OnCo record `tent4a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TENT4A (Terminal nucleotidyltransferase 4A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Terminal nucleotidyltransferase that catalyses preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilisation by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.31, affected pathway 0.89, genetic association 0.12).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: terminal nucleotidyltransferase 4A; Terminal nucleotidyltransferase 4A; TRF4; LAK-1; TRF4-1; PAPD7
- Tags: cancer-genes-wave
- Symbol: TENT4A
- Class: enzyme
- Biology: Terminal nucleotidyltransferase that catalyses preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilisation by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. Location: Cytoplasm; Nucleus, nucleoplasm (UniProt). Locus 5p15.31 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16705: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16705
- UniProt Q5XG87: https://www.uniprot.org/uniprotkb/Q5XG87/entry
- NCBI Gene 11044: https://www.ncbi.nlm.nih.gov/gene/11044
- Ensembl ENSG00000112941: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112941

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/tent4a.json