# TENT5C

Source: https://onco.cc/targets/tent5c/  
OnCo record `tent5c` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TENT5C (Terminal nucleotidyltransferase 5C) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma, Skin cancer, Colorectal cancer and 1 more.

## Summary

Catalyses the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.

Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.92, animal model 0.44, genetic association 0.10, somatic mutation 0.92). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Plasma Cell Myeloma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: terminal nucleotidyltransferase 5C; Terminal nucleotidyltransferase 5C; FLJ20202; FAM46C
- Tags: cancer-genes-wave
- Symbol: TENT5C
- Class: enzyme
- Biology: Catalyses the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein. Location: Nucleus; Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 1p12 (HGNC).
- Where found: Multiple myeloma: Open Targets association 0.54 with plasma cell myeloma (MONDO_0009693); IntOGen driver in 3 cohorts (PCM); Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898); Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575); Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24712: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24712
- UniProt Q5VWP2: https://www.uniprot.org/uniprotkb/Q5VWP2/entry
- NCBI Gene 54855: https://www.ncbi.nlm.nih.gov/gene/54855
- Ensembl ENSG00000183508: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183508

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/tent5c.json