# TFAP4

Source: https://onco.cc/targets/tfap4/  
OnCo record `tfap4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TFAP4 (Transcription factor AP-4) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Burkitt lymphoma.

## Summary

Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. IntOGen calls it a driver in 3 cohorts (2 activating, 1 loss-of-function), covering Burkitt Lymphoma, Non-Hodgkin Lymphoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transcription factor AP-4; Transcription factor AP-4; AP-4; bHLHc41
- Tags: cancer-genes-wave
- Symbol: TFAP4
- Class: transcription
- Biology: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Location: Nucleus (UniProt). Locus 16p13.3 (HGNC).
- Where found: Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (NHL); Burkitt lymphoma: CIViC evidence names this disease; IntOGen driver in 2 cohorts (BL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11745: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11745
- UniProt Q01664: https://www.uniprot.org/uniprotkb/Q01664/entry
- NCBI Gene 7023: https://www.ncbi.nlm.nih.gov/gene/7023
- Ensembl ENSG00000090447: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000090447

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Burkitt lymphoma](https://onco.cc/cancers/burkitt-lymphoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/tfap4.json