# TFF3

Source: https://onco.cc/targets/tff3/  
OnCo record `tff3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TFF3 (Trefoil factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.

## Summary

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).

CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Tamoxifen and Aminoglutethimide.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: trefoil factor 3; Trefoil factor 3
- Tags: cancer-genes-wave
- Symbol: TFF3
- Class: other
- Biology: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). Location: Secreted, extracellular space, extracellular matrix; Cytoplasm (UniProt). Locus 21q22.3 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11757: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11757
- UniProt Q07654: https://www.uniprot.org/uniprotkb/Q07654/entry
- NCBI Gene 7033: https://www.ncbi.nlm.nih.gov/gene/7033
- Ensembl ENSG00000160180: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000160180

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/tff3.json