# TFG

Source: https://onco.cc/targets/tfg/  
OnCo record `tfg` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TFG (trafficking from ER to golgi regulator) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Lung cancer.

## Summary

Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.

Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.93, genetic association 0.08, somatic mutation 0.79). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: trafficking from ER to golgi regulator; TF6; FLJ36137; SPG57
- Tags: cancer-genes-wave
- Symbol: TFG
- Class: oncogene
- Biology: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Location: Endoplasmic reticulum (UniProt). Locus 3q12.2 (HGNC).
- Where found: Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11758: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11758
- UniProt Q92734: https://www.uniprot.org/uniprotkb/Q92734/entry
- NCBI Gene 10342: https://www.ncbi.nlm.nih.gov/gene/10342
- Ensembl ENSG00000114354: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114354

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/)

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JSON: https://onco.cc/api/v1/entities/tfg.json