# TG4050

Source: https://onco.cc/drugs/tg4050/  
OnCo record `tg4050` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TG4050 is an experimental individualised neoantigen therapeutic vaccine from Transgene, in phase 2 trials for HPV-negative head and neck squamous cell carcinoma and ovarian cancer.

## Summary

TG4050 is an individualised neoantigen therapeutic vaccine (myvac platform) from Transgene. The lead individualised neoantigen therapeutic vaccine from Transgene's myvac platform, given as a single agent after surgery. Its furthest stage is phase 2, for HPV-negative head and neck squamous cell carcinoma (adjuvant) and ovarian cancer. ClinicalTrials.gov registers it in 2 studies linked below. Transgene: randomised multicentre phase 2 part of a phase 1/2 trial (NCT04183166, active, not recruiting). An ovarian cancer phase 1 (NCT03839524) is completed. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-2
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: TG4050
- Modality: Individualised neoantigen therapeutic vaccine (myvac platform)
- Mechanism: The lead individualised neoantigen therapeutic vaccine from Transgene's myvac platform, given as a single agent after surgery.

## Sources

- Transgene: transgene.com: https://www.transgene.com/tg4050/
- ClinicalTrials.gov: trials of TG4050: https://clinicaltrials.gov/search?intr=TG4050

## Connected records

- cancers: [HPV-negative head and neck squamous cell carcinoma (including HPV-negative oropharyngeal cancer)](https://onco.cc/cancers/hpv-negative-head-and-neck-cancer/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- companies: [Transgene](https://onco.cc/companies/transgene/)
- trials: [A Clinical Trial Evaluating TG4050 in Head and Neck Cancer](https://onco.cc/trials/nct04183166/), [A Trial Evaluating TG4050 in Ovarian Carcinoma.](https://onco.cc/trials/nct03839524/)

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JSON: https://onco.cc/api/v1/entities/tg4050.json