# TGFA

Source: https://onco.cc/targets/tgfa/  
OnCo record `tgfa` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TGFA (Protransforming growth factor alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.

## Summary

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.76, animal model 0.69, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transforming growth factor alpha; Protransforming growth factor alpha
- Tags: cancer-genes-wave
- Symbol: TGFA
- Class: other
- Biology: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 2p13.3 (HGNC).
- Where found: Head and neck squamous cell carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11765: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11765
- UniProt P01135: https://www.uniprot.org/uniprotkb/P01135/entry
- NCBI Gene 7039: https://www.ncbi.nlm.nih.gov/gene/7039
- Ensembl ENSG00000163235: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163235

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/)
- pathways: [Renal cell carcinoma (KEGG map)](https://onco.cc/pathways/renal-cell-carcinoma-signalling/)

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JSON: https://onco.cc/api/v1/entities/tgfa.json