# TGFB3

Source: https://onco.cc/targets/tgfb3/  
OnCo record `tgfb3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TGFB3 (Transforming growth factor beta-3 proprotein) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Myelodysplastic syndromes / neoplasms.

## Summary

Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3.

Open Targets scores its association with cancer at 0.45 (direct and indirect evidence; datatypes literature 0.93, animal model 0.69, genetic association 0.42, clinical 0.58).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transforming growth factor beta 3; Transforming growth factor beta-3 proprotein; ARVD1
- Tags: cancer-genes-wave
- Symbol: TGFB3
- Class: other
- Biology: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3. Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix. Location: Secreted, extracellular space, extracellular matrix; Secreted (UniProt). Locus 14q24.3 (HGNC).
- Where found: Myelodysplastic syndromes / neoplasms: Open Targets association 0.56 with myelodysplastic syndrome (MONDO_0018881)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.92. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11769: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11769
- UniProt P10600: https://www.uniprot.org/uniprotkb/P10600/entry
- NCBI Gene 7043: https://www.ncbi.nlm.nih.gov/gene/7043
- Ensembl ENSG00000119699: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119699

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/)

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JSON: https://onco.cc/api/v1/entities/tgfb3.json