# TGIF1

Source: https://onco.cc/targets/tgif1/  
OnCo record `tgif1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TGIF1 (Homeobox protein TGIF1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.

## Summary

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Colorectal Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TGFB induced factor homeobox 1; Homeobox protein TGIF1; HPE4
- Tags: cancer-genes-wave
- Symbol: TGIF1
- Class: tumor-suppressor
- Biology: Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signalling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. Location: Nucleus (UniProt). Locus 18p11.31 (HGNC).
- Where found: Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11776: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11776
- UniProt Q15583: https://www.uniprot.org/uniprotkb/Q15583/entry
- NCBI Gene 7050: https://www.ncbi.nlm.nih.gov/gene/7050
- Ensembl ENSG00000177426: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177426

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/tgif1.json