# THE-0504

Source: https://onco.cc/drugs/the-0504/  
OnCo record `the-0504` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

THE-0504 is an experimental human ferritin nanocage drug carrier loaded with a topoisomerase I inhibitor from Thena Biotech, in phase 1 trials for small cell lung cancer, colorectal carcinoma and pancreatic adenocarcinoma and other cancers.

## Summary

THE-0504 is a human ferritin (HFt) nanocage drug carrier loaded with a topoisomerase I inhibitor from Thena Biotech. A human ferritin cage, activated by tumour proteases, that carries the topoisomerase I inhibitor Genz-644282 into cells with the CD71 receptor, aiming to avoid the toxicity of other CD71-targeted drugs. Its furthest stage is phase 1, for small cell lung cancer, colorectal carcinoma, pancreatic adenocarcinoma and gastric cancer. ClinicalTrials.gov registers it in one study linked below. Single-centre phase 1 NANOFER-THE-0504 NCT07646106 recruiting. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: THE-0504
- Modality: Human ferritin (HFt) nanocage drug carrier loaded with a topoisomerase I inhibitor
- Mechanism: A human ferritin cage, activated by tumour proteases, that carries the topoisomerase I inhibitor Genz-644282 into cells with the CD71 receptor, aiming to avoid the toxicity of other CD71-targeted drugs.

## Sources

- Thena Biotech: thenabiotech.com: https://thenabiotech.com/
- Thena Biotech: ebi.ac.uk: https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC7877078&resultType=core&format=json
- Thena Biotech: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT07646106
- ClinicalTrials.gov: trials of THE-0504: https://clinicaltrials.gov/search?intr=THE-0504

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/), [Triple-negative breast cancer (TNBC)](https://onco.cc/cancers/tnbc/)
- targets: [TFRC](https://onco.cc/targets/tfrc/)
- companies: [Thena Biotech](https://onco.cc/companies/thena-biotech/)
- trials: [THE-0504 in Patients With Solid Tumors](https://onco.cc/trials/nct07646106/)

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JSON: https://onco.cc/api/v1/entities/the-0504.json