# ThinPrep Pap Test and ThinPrep processors (Hologic)

Source: https://onco.cc/drugs/thinprep/  
OnCo record `thinprep` (Test). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The liquid-based Pap test, approved in 1996, in which cells go into a vial of fluid rather than straight onto a slide; its preservative is the collection medium named in the FDA approvals of several HPV tests.

## Summary

The ThinPrep 2000 processor (Hologic, PMA P950039) was approved by the FDA on 20 May 1996 under the product code for automated cervical cytology slide processors. The ThinPrep PreservCyt solution it uses is the collection medium named in the FDA approvals of the cobas, Aptima, Alinity m and BD Onclarity HPV tests and of the CINtec PLUS dual stain.

## Fields

- Kind: Test
- Status: approved
- Last checked: 2026-11-04
- Also known as: ThinPrep Pap test; ThinPrep 2000; PreservCyt
- Tags: test; screening-test
- Brand: ThinPrep
- Modality: Liquid-based cervical cytology (Pap test) slide processor
- Mechanism: Cervical cells are placed in a preservative liquid instead of being smeared on glass; a processor prepares a thin layer of cells on a slide for a cytologist to read.
- Approvals: US 1996: Liquid-based cervical cytology slide preparation (PMA P950039)

## Sources

- FDA PMA P950039: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P950039

## Connected records

- drugs: [Aptima HPV Assay and Aptima HPV 16 18/45 Genotype Assay](https://onco.cc/drugs/aptima-hpv/), [Automated Pap slide readers: BD FocalPoint and the ThinPrep Imaging System](https://onco.cc/drugs/automated-pap-screening-readers/), [BD SurePath liquid-based Pap test and PrepStain slide processor](https://onco.cc/drugs/bd-surepath/), [CINtec PLUS Cytology (p16/Ki-67 dual stain)](https://onco.cc/drugs/cintec-plus-cytology/), [Genius Digital Diagnostics System with Genius Cervical AI (Hologic)](https://onco.cc/drugs/genius-digital-diagnostics/)
- collections: [FDA medical device databases (PMA, 510(k), De Novo)](https://onco.cc/collections/fda-device-databases/)
- cancers: [Cervical cancer](https://onco.cc/cancers/cervical/)
- fronts: [Diagnostics & Biomarkers](https://onco.cc/fronts/diagnostics/), [Early Detection & Screening](https://onco.cc/fronts/early-detection/)
- technologies: [HPV DNA testing and self-sampling](https://onco.cc/technologies/hpv-testing/)
- companies: [Hologic](https://onco.cc/companies/hologic/)
- terms: [Cervical precancer (CIN, HSIL/LSIL)](https://onco.cc/terms/cin-hsil/), [Screening](https://onco.cc/terms/screening/)

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