# THRA

Source: https://onco.cc/targets/thra/  
OnCo record `thra` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

THRA (Thyroid hormone receptor alpha) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.

## Summary

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.90, animal model 0.55, genetic association 0.00, clinical 0.91).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: thyroid hormone receptor alpha; Thyroid hormone receptor alpha; EAR-7.1/EAR-7.2; THRA3; AR7; NR1A1; TRalpha; TRalpha1; TRalpha2; c-ERBA-1; c-erbA; THRalpha; THRalpha1; THRalpha2; THRA1; THRA2; ERBA1
- Tags: cancer-genes-wave
- Symbol: THRA
- Class: transcription
- Biology: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. Location: Nucleus; Cytoplasm (UniProt). Locus 17q21.1 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.57 with thyroid cancer (MONDO_0002108)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.91. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11796: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11796
- UniProt P10827: https://www.uniprot.org/uniprotkb/P10827/entry
- NCBI Gene 7067: https://www.ncbi.nlm.nih.gov/gene/7067
- Ensembl ENSG00000126351: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126351

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/thra.json