# THRAP3

Source: https://onco.cc/targets/thrap3/  
OnCo record `thrap3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

THRAP3 (Thyroid hormone receptor-associated protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.

## Summary

Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Acute Myeloid Leukaemia.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: thyroid hormone receptor associated protein 3; Thyroid hormone receptor-associated protein 3; TRAP150; BCLAF2
- Tags: cancer-genes-wave
- Symbol: THRAP3
- Class: tumor-suppressor
- Biology: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Location: Nucleus; Nucleus, nucleoplasm; Nucleus speckle (UniProt). Locus 1p34.3 (HGNC).
- Where found: Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:22964: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22964
- UniProt Q9Y2W1: https://www.uniprot.org/uniprotkb/Q9Y2W1/entry
- NCBI Gene 9967: https://www.ncbi.nlm.nih.gov/gene/9967
- Ensembl ENSG00000054118: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000054118

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)

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JSON: https://onco.cc/api/v1/entities/thrap3.json