# THRB

Source: https://onco.cc/targets/thrb/  
OnCo record `thrb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

THRB (Thyroid hormone receptor beta) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.

## Summary

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.95, animal model 0.75, genetic association 0.46, clinical 0.91).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: thyroid hormone receptor beta; Thyroid hormone receptor beta; THRB1; THRB2; NR1A2; THR1; ERBA-BETA; TRbeta; TRb; c-erbA-beta; c-erbA-2; THRbeta; TRbeta1; THRbeta1; Thrbeta2; ERBA2
- Tags: cancer-genes-wave
- Symbol: THRB
- Class: transcription
- Biology: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Location: Nucleus (UniProt). Locus 3p24.2 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.58 with thyroid cancer (MONDO_0002108)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.91. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11799: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11799
- UniProt P10828: https://www.uniprot.org/uniprotkb/P10828/entry
- NCBI Gene 7068: https://www.ncbi.nlm.nih.gov/gene/7068
- Ensembl ENSG00000151090: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000151090

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/thrb.json