# ThyGeNEXT and ThyraMIR v2

Source: https://onco.cc/drugs/thygenext-thyramir/  
OnCo record `thygenext-thyramir` (Test). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A pair of tests on a thyroid nodule needle sample, one reading DNA and RNA fusions and one reading small regulatory RNAs, to judge whether an uncertain nodule is likely to be cancer.

## Summary

Interpace Biosciences describes ThyGeNEXT as a DNA mutation panel plus an RNA fusion panel (ALK, BRAF, NTRK, PPARG, RET, THADA) and mRNA markers (NKX2-1, PAX8, TBP, USP33), billed under PLA code 0245U, "mutation analysis of 10 genes and 37 RNA fusions and expression of 4 mRNA markers"; ThyraMIR v2 "analyzes microRNA signatures". In a multicentre study of indeterminate nodules the combined test had 95 per cent sensitivity, 90 per cent specificity, a 97 per cent negative predictive value and a 75 per cent positive predictive value (Lupo 2020).

## Fields

- Kind: Test
- Status: established
- Last checked: 2026-11-04
- Also known as: ThyGeNEXT; ThyraMIR; Interpace multiplatform thyroid test
- Tags: test; rna
- Brand: ThyGeNEXT / ThyraMIR
- Modality: DNA mutation, RNA fusion and microRNA classifier (thyroid nodule aspirates)
- Mechanism: ThyGeNEXT sequences DNA mutations, RNA fusions and four mRNA markers; ThyraMIR v2 measures a microRNA signature; together they classify an indeterminate thyroid nodule.

## Sources

- Interpace: ThyGeNEXT and ThyraMIR: https://thygenext-thyramir.com/

## Connected records

- drugs: [Afirma Genomic Sequencing Classifier](https://onco.cc/drugs/afirma/), [ThyroSeq v3 Genomic Classifier](https://onco.cc/drugs/thyroseq/)
- cancers: [Thyroid cancer](https://onco.cc/cancers/thyroid/)
- technologies: [Thyroid nodule FNA, Bethesda cytology & molecular classifiers](https://onco.cc/technologies/thyroid-fna-molecular/)
- companies: [Interpace Biosciences](https://onco.cc/companies/interpace-biosciences/)
- key papers: [Multiplatform molecular test performance in indeterminate thyroid nodules](https://onco.cc/key-papers/paper-lupo-multiplatform-thyroid-nodule-diagn-cytopathol-2020/)

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