# TLK2

Source: https://onco.cc/targets/tlk2/  
OnCo record `tlk2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TLK2 (Serine/threonine-protein kinase tousled-like 2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.

## Summary

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Go6983 and GF109203X.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tousled like kinase 2; Serine/threonine-protein kinase tousled-like 2; PKU-ALPHA; MGC44450
- Tags: cancer-genes-wave
- Symbol: TLK2
- Class: kinase
- Biology: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Location: Nucleus; Nucleus, nucleoplasm; Cytoplasm, perinuclear region; Cytoplasm, cytoskeleton (UniProt). Locus 17q23.2 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt keyword "DNA damage". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11842: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11842
- UniProt Q86UE8: https://www.uniprot.org/uniprotkb/Q86UE8/entry
- NCBI Gene 11011: https://www.ncbi.nlm.nih.gov/gene/11011
- Ensembl ENSG00000146872: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000146872

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/tlk2.json