# TLN1

Source: https://onco.cc/targets/tln1/  
OnCo record `tln1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TLN1 (Talin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organise the assembly of cortical microtubule stabilising complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.83, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: talin 1; Talin-1; ILWEQ
- Tags: cancer-genes-wave
- Symbol: TLN1
- Class: other
- Biology: High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organise the assembly of cortical microtubule stabilising complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. Location: Cell projection, ruffle membrane; Cytoplasm, cytoskeleton; Cell surface; Cell junction, focal adhesion (UniProt). Locus 9p13.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11845: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11845
- UniProt Q9Y490: https://www.uniprot.org/uniprotkb/Q9Y490/entry
- NCBI Gene 7094: https://www.ncbi.nlm.nih.gov/gene/7094
- Ensembl ENSG00000137076: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137076

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/tln1.json