# TLX1

Source: https://onco.cc/targets/tlx1/  
OnCo record `tlx1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TLX1 (T-cell leukaemia homeobox protein 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.

## Summary

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.84, somatic mutation 0.95).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: T cell leukemia homeobox 1; T-cell leukemia homeobox protein 1; TCL3; HOX11
- Tags: cancer-genes-wave
- Symbol: TLX1
- Class: other
- Biology: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. Location: Nucleus (UniProt). Locus 10q24.31 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5056: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5056
- UniProt P31314: https://www.uniprot.org/uniprotkb/P31314/entry
- NCBI Gene 3195: https://www.ncbi.nlm.nih.gov/gene/3195
- Ensembl ENSG00000107807: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107807

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/tlx1.json