# TLX3

Source: https://onco.cc/targets/tlx3/  
OnCo record `tlx3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TLX3 (T-cell leukaemia homeobox protein 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

UniProt has no function text for O43711; HGNC names it "T cell leukaemia homeobox 3".

Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.73, genetic association 0.16, somatic mutation 0.93).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: T cell leukemia homeobox 3; T-cell leukemia homeobox protein 3; HOX11L2
- Tags: cancer-genes-wave
- Symbol: TLX3
- Class: other
- Biology: UniProt has no function text for O43711; HGNC names it "T cell leukaemia homeobox 3". Location: Nucleus (UniProt). Locus 5q35.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13532: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13532
- UniProt O43711: https://www.uniprot.org/uniprotkb/O43711/entry
- NCBI Gene 30012: https://www.ncbi.nlm.nih.gov/gene/30012
- Ensembl ENSG00000164438: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164438

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/tlx3.json