# TMEM127

Source: https://onco.cc/targets/tmem127/  
OnCo record `tmem127` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TMEM127 (Transmembrane protein 127) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Melanoma.

## Summary

Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor.

Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.79, literature 0.19, genetic association 0.59, somatic mutation 0.93, animal model 0.47).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transmembrane protein 127; Transmembrane protein 127; FLJ20507; FLJ22257
- Tags: cancer-genes-wave
- Symbol: TMEM127
- Class: other
- Biology: Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor. Location: Cell membrane; Cytoplasm (UniProt). Locus 2q11.2 (HGNC).
- Where found: Neuroendocrine tumours: Open Targets association 0.78 with neuroendocrine neoplasm (MONDO_0019496); Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:26038: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26038
- UniProt O75204: https://www.uniprot.org/uniprotkb/O75204/entry
- NCBI Gene 55654: https://www.ncbi.nlm.nih.gov/gene/55654
- Ensembl ENSG00000135956: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135956

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/)

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JSON: https://onco.cc/api/v1/entities/tmem127.json