# TMEM17

Source: https://onco.cc/targets/tmem17/  
OnCo record `tmem17` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TMEM17 (Transmembrane protein 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Transmembrane component of the tectonic-like complex, a complex localised at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signalling.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.68).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transmembrane protein 17; Transmembrane protein 17; FLJ34583
- Tags: cancer-genes-wave
- Symbol: TMEM17
- Class: other
- Biology: Transmembrane component of the tectonic-like complex, a complex localised at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signalling. Location: Cell projection, cilium membrane (UniProt). Locus 2p15 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:26623: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26623
- UniProt Q86X19: https://www.uniprot.org/uniprotkb/Q86X19/entry
- NCBI Gene 200728: https://www.ncbi.nlm.nih.gov/gene/200728
- Ensembl ENSG00000186889: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186889

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/tmem17.json