# TMEM238L

Source: https://onco.cc/targets/tmem238l/  
OnCo record `tmem238l` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TMEM238L (Transmembrane protein 238-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: transmembrane protein 238 like; Transmembrane protein 238-like; FORCP; LINC00675
- Tags: cancer-genes-wave
- Symbol: TMEM238L
- Class: other
- Biology: May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity. Location: Endoplasmic reticulum membrane (UniProt). Locus 17p13.1-p12 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:44356: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:44356
- UniProt A6NJY4: https://www.uniprot.org/uniprotkb/A6NJY4/entry
- NCBI Gene 100289255: https://www.ncbi.nlm.nih.gov/gene/100289255
- Ensembl ENSG00000263429: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000263429

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/tmem238l.json