# TNFRSF10B

Source: https://onco.cc/targets/tnfrsf10b/  
OnCo record `tnfrsf10b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TNFRSF10B (Tumour necrosis factor receptor superfamily member 10B) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes genetic literature 0.30, clinical 0.20, literature 0.98, genetic association 0.79, animal model 0.27).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TNF receptor superfamily member 10b; Tumor necrosis factor receptor superfamily member 10B; DR5; KILLER; TRICK2A; TRAIL-R2; TRICKB; CD262; TRAILR2
- Tags: cancer-genes-wave
- Symbol: TNFRSF10B
- Class: other
- Biology: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Location: Membrane (UniProt). Locus 8p21.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.20. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11905: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11905
- UniProt O14763: https://www.uniprot.org/uniprotkb/O14763/entry
- NCBI Gene 8795: https://www.ncbi.nlm.nih.gov/gene/8795
- Ensembl ENSG00000120889: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120889

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- pathways: [Extrinsic apoptosis (death receptors)](https://onco.cc/pathways/extrinsic-apoptosis-death-receptors/)

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JSON: https://onco.cc/api/v1/entities/tnfrsf10b.json