# TNFRSF13B

Source: https://onco.cc/targets/tnfrsf13b/  
OnCo record `tnfrsf13b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TNFRSF13B (Tumour necrosis factor receptor superfamily member 13B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Multiple myeloma.

## Summary

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.93, animal model 0.48, genetic association 0.71).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TNF receptor superfamily member 13B; Tumor necrosis factor receptor superfamily member 13B; CD267; IGAD2
- Tags: cancer-genes-wave
- Symbol: TNFRSF13B
- Class: other
- Biology: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Location: Membrane (UniProt). Locus 17p11.2 (HGNC).
- Where found: Multiple myeloma: Open Targets association 0.56 with plasma cell myeloma (MONDO_0009693)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18153: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18153
- UniProt O14836: https://www.uniprot.org/uniprotkb/O14836/entry
- NCBI Gene 23495: https://www.ncbi.nlm.nih.gov/gene/23495
- Ensembl ENSG00000240505: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000240505

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/)

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JSON: https://onco.cc/api/v1/entities/tnfrsf13b.json