# GITR (TNFRSF18)

Source: https://onco.cc/targets/tnfrsf18/  
OnCo record `tnfrsf18` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GITR is an accelerator on T cells that agonist antibodies tried to press to boost immunotherapy. Several reached early trials; one programme was dropped for reasons unrelated to safety.

## Summary

TNFRSF18 (chromosome 1p36.33) encodes GITR, the receptor for TNFSF18 (GITR ligand), which seems to be involved in interactions between activated T lymphocytes and endothelial cells and in the regulation of T-cell-receptor-mediated cell death, and mediates NF-kappa-B activation through the TRAF2/NIK pathway; it is expressed in lymph node and peripheral blood leukocytes and weakly in spleen (UniProt Q9Y5U5). BMS-986156, a GITR agonist, completed phase 1/2 alone and with nivolumab (NCT02598960); TRX518 was discontinued for reasons unrelated to safety (NCT03861403).

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: GITR; AITR; CD357; TNF receptor superfamily member 18
- Tags: checkpoint-map
- Symbol: TNFRSF18
- Class: surface-antigen
- Biology: A TNF-receptor-superfamily costimulator on activated and regulatory T cells.
- Where found: Lymph node and peripheral blood leukocytes (UniProt Q9Y5U5)

## Notes

- Prevalence not recorded: HGNC and UniProt carry no positivity rates.

## Sources

- HGNC HGNC:11914: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11914
- UniProt Q9Y5U5: https://www.uniprot.org/uniprotkb/Q9Y5U5/entry
- NCBI Gene 8784: https://www.ncbi.nlm.nih.gov/gene/8784
- ClinicalTrials.gov NCT02598960: https://clinicaltrials.gov/study/NCT02598960

## Connected records

- targets: [CD137 (4-1BB, TNFRSF9)](https://onco.cc/targets/cd137/), [OX40 (TNFRSF4)](https://onco.cc/targets/tnfrsf4/)
- drugs: [Nivolumab](https://onco.cc/drugs/nivolumab/)
- pathways: [The cancer-immunity cycle](https://onco.cc/pathways/cancer-immunity-cycle/)
- terms: [Checkpoint (two meanings)](https://onco.cc/terms/checkpoint/)

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JSON: https://onco.cc/api/v1/entities/tnfrsf18.json