# TNFSF10

Source: https://onco.cc/targets/tnfsf10/  
OnCo record `tnfsf10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TNFSF10 (Tumour necrosis factor ligand superfamily member 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.25, genetic association 0.62).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TNF superfamily member 10; Tumor necrosis factor ligand superfamily member 10; TRAIL; Apo-2L; TL2; CD253; TANCR
- Tags: cancer-genes-wave
- Symbol: TNFSF10
- Class: other
- Biology: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Location: Cell membrane; Secreted (UniProt). Locus 3q26.31 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11925: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11925
- UniProt P50591: https://www.uniprot.org/uniprotkb/P50591/entry
- NCBI Gene 8743: https://www.ncbi.nlm.nih.gov/gene/8743
- Ensembl ENSG00000121858: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121858

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- pathways: [Extrinsic apoptosis (death receptors)](https://onco.cc/pathways/extrinsic-apoptosis-death-receptors/)

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JSON: https://onco.cc/api/v1/entities/tnfsf10.json