# TNS1

Source: https://onco.cc/targets/tns1/  
OnCo record `tns1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TNS1 (Tensin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.91, animal model 0.39, genetic association 0.65).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tensin 1; Tensin-1; DKFZp586K0617; PPP1R155; MXRA6
- Tags: cancer-genes-wave
- Symbol: TNS1
- Class: enzyme
- Biology: May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarisation and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton. Location: Cell surface; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 2q35 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11973: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11973
- UniProt Q9HBL0: https://www.uniprot.org/uniprotkb/Q9HBL0/entry
- NCBI Gene 7145: https://www.ncbi.nlm.nih.gov/gene/7145
- Ensembl ENSG00000079308: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079308

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/tns1.json