# TOE1

Source: https://onco.cc/targets/toe1/  
OnCo record `toe1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TOE1 (Target of EGR1 protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.73, affected pathway 0.25, genetic association 0.77).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: target of EGR1, exonuclease; Target of EGR1 protein 1; hCaf1z; TOE-1
- Tags: cancer-genes-wave
- Symbol: TOE1
- Class: other
- Biology: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing. Location: Nucleus, nucleolus; Nucleus speckle (UniProt). Locus 1p34.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:15954: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15954
- UniProt Q96GM8: https://www.uniprot.org/uniprotkb/Q96GM8/entry
- NCBI Gene 114034: https://www.ncbi.nlm.nih.gov/gene/114034
- Ensembl ENSG00000132773: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132773

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/toe1.json