# TOX3

Source: https://onco.cc/targets/tox3/  
OnCo record `tox3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TOX3 (TOX high mobility group box family member 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.

## Summary

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.72).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: TOX high mobility group box family member 3; CAGF9; TNRC9
- Tags: cancer-genes-wave
- Symbol: TOX3
- Class: transcription
- Biology: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the oestrogen-responsive or BCL-2 promoters. Required for depolarisation-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the oestrogen-responsive C3 promoter region. Location: Nucleus (UniProt). Locus 16q12.1 (HGNC).
- Where found: Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11972: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11972
- UniProt O15405: https://www.uniprot.org/uniprotkb/O15405/entry
- NCBI Gene 27324: https://www.ncbi.nlm.nih.gov/gene/27324
- Ensembl ENSG00000103460: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103460

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/tox3.json