# TPCN2

Source: https://onco.cc/targets/tpcn2/  
OnCo record `tpcn2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TPCN2 (Two pore channel protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.

## Summary

Intracellular channel initially characterised as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localises to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.79, animal model 0.25, genetic association 0.68).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: two pore segment channel 2; Two pore channel protein 2; TPC2
- Tags: cancer-genes-wave
- Symbol: TPCN2
- Class: other
- Biology: Intracellular channel initially characterised as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localises to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy. Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2. As calcium channel, it increases the pH in the lysosomal lumen, as sodium channel, it promotes lysosomal exocytosis. Plays a crucial role in endolysosomal trafficking in the endolysosomal degradation pathway and is potentially involved in the homeostatic control of many macromolecules and cell metabolites. Location: Late endosome membrane; Lysosome membrane; Melanosome membrane (UniProt). Locus 11q13.3 (HGNC).
- Where found: Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20820: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20820
- UniProt Q8NHX9: https://www.uniprot.org/uniprotkb/Q8NHX9/entry
- NCBI Gene 219931: https://www.ncbi.nlm.nih.gov/gene/219931
- Ensembl ENSG00000162341: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162341

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/tpcn2.json