# TPM4

Source: https://onco.cc/targets/tpm4/  
OnCo record `tpm4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TPM4 (Tropomyosin alpha-4 chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes affected pathway 0.76, literature 0.96, genetic association 0.19, somatic mutation 0.80, animal model 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tropomyosin 4; Tropomyosin alpha-4 chain
- Tags: cancer-genes-wave
- Symbol: TPM4
- Class: other
- Biology: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilising cytoskeleton actin filaments. Binds calcium. Plays a role in platelet biogenesis. Location: Cytoplasm, cytoskeleton (UniProt). Locus 19p13.12-p13.11 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12013: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12013
- UniProt P67936: https://www.uniprot.org/uniprotkb/P67936/entry
- NCBI Gene 7171: https://www.ncbi.nlm.nih.gov/gene/7171
- Ensembl ENSG00000167460: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167460

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/tpm4.json