# TPR

Source: https://onco.cc/targets/tpr/  
OnCo record `tpr` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TPR (Nucleoprotein TPR) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Medulloblastoma.

## Summary

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalisation in interphase, and in the mitotic spindle checkpoint signalling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner.

Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.76, genetic association 0.04, somatic mutation 0.80). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Hepatocellular Carcinoma, Medulloblastoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: translocated promoter region, nuclear basket protein; Nucleoprotein TPR
- Tags: cancer-genes-wave
- Symbol: TPR
- Class: tumor-suppressor
- Biology: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalisation in interphase, and in the mitotic spindle checkpoint signalling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Location: Nucleus; Nucleus membrane; Nucleus envelope; Nucleus, nuclear pore complex (UniProt). Locus 1q31.1 (HGNC).
- Where found: Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Medulloblastoma: IntOGen driver in 1 cohort (MBL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12017: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12017
- UniProt P12270: https://www.uniprot.org/uniprotkb/P12270/entry
- NCBI Gene 7175: https://www.ncbi.nlm.nih.gov/gene/7175
- Ensembl ENSG00000047410: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000047410

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/)

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JSON: https://onco.cc/api/v1/entities/tpr.json