# TPT1

Source: https://onco.cc/targets/tpt1/  
OnCo record `tpt1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TPT1 (Translationally-controlled tumour protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.

## Summary

Involved in calcium binding and microtubule stabilisation. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilisation of TSC22D1 protein.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sertraline.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: tumor protein, translationally-controlled 1; Translationally-controlled tumor protein; fortilin
- Tags: cancer-genes-wave
- Symbol: TPT1
- Class: other
- Biology: Involved in calcium binding and microtubule stabilisation. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilisation of TSC22D1 protein. Location: Cytoplasm (UniProt). Locus 13q14.13 (HGNC).
- Where found: Melanoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12022: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12022
- UniProt P13693: https://www.uniprot.org/uniprotkb/P13693/entry
- NCBI Gene 7178: https://www.ncbi.nlm.nih.gov/gene/7178
- Ensembl ENSG00000133112: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000133112

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)

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JSON: https://onco.cc/api/v1/entities/tpt1.json